Vitamin B-12 status in infancy predicts development and cognitive functioning 5 years later in Nepalese children

Authors: Ingrid Kvestad; Mari Hysing; Merina Shrestha; Manjeswori Ulak; Andrew Thorne-Lyman; Sigrun Henjum; Per Ueland; Oyvind Midttun; Wafaie Fawzi; Ram Chandyo; Prakash Shrestha; Tor Strand Publisher: American Journal of Clinical Nutrition

We measured the associations between vitamin B-12 status in infancy (2–12 mo) and the development and cognitive functioning in Nepalese children 5 y later. Vitamin B-12 status was assessed in infancy with the use of plasma cobalamin, total homocysteine (tHcy), and methylmalonic acid (MMA). At 5 y of age, we measured development with the use of the Ages and Stages Questionnaire, 3rd edition (ASQ- 3), and cognitive functioning by using the Developmental Neuropsychological Assessment, 2nd edition (NEPSY II), in 320 children. In regression models, we estimated the associations between vitamin B-12 status, including a combined indicator of vitamin B-12 status (3cB12) and scores on the ASQ-3 and NEPSY II subtests.